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Summary of Studies of
Brain Cancer, PCBs and
Dioxins
(Each entry represents one finding in the studies, unless otherwise
noted. Some studies had multiple findings.)
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mortality from brain cancer was modestly increased among men with up to
10,000 hours PCB exposure
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no deaths from brain cancer occurred among the most highly PCB exposed
men
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a five-year lag time increased the brain cancer rate
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More deaths were observed than expected for cancer of the brain and nervous
system
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The average estimated cumulative PCB dose for the cases of brain cancer
was greater than for other workers
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PCBs are known to deposit preferentially in nervous tissue
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Study examined two PCB-exposed workers with brain cancer
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Researchers urge more studies of link between PCBs and brain cancer
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increased incidence of brain cancer among workers who had more than twice
the estimated cumulative PCB dose than the comparison group
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PCB-exposed workers experienced excess in the number of deaths resulting
from brain cancer
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elevated risks of brain cancer have been noted in electrical workers, who
tend to be exposed to PCBs
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Brain cancer was significantly increased in females exposed to dioxin [certain
PCBs are dioxin-like, or contaminated with dioxin]
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A statistically significant higher concentration of PCB was found in extracted
lipids of adipose tissue samples from terminal brain cancer patients
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Nerve Growth Factor (NGF) was more potent in the presence of PCBs
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PCBs have the potential to influence the NGF neurotrophic system
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children of fathers exposed to dioxin experienced increased rates of brain
cancer
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there is suggestive evidence that brain tumors are associated with parental
exposures to chemicals
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causes of endocrine-related cancers or susceptibility to cancer may be
a result of developmental exposures rather than exposures existing at or
near the time of tumor detection
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A glioma case [brain cancer] was associated with dioxin exposure
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alteration of cellular redox balance may mediate the dioxin-induced inhibition
of proliferation in human neuronal cells.
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