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PCB Human Health Risks Fox River Watch Site Index

Summary of Studies of 
Brain Cancer, PCBs and Dioxins

(Each entry represents one finding in the studies, unless otherwise noted. Some studies had multiple findings.) 

  • mortality from brain cancer was modestly increased among men with up to 10,000 hours PCB exposure
  • no deaths from brain cancer occurred among the most highly PCB exposed men
  • a five-year lag time increased the brain cancer rate
  • More deaths were observed than expected for cancer of the brain and nervous system
  • The average estimated cumulative PCB dose for the cases of brain cancer was greater than for other workers
  • PCBs are known to deposit preferentially in nervous tissue
  • Study examined two PCB-exposed workers with brain cancer
  • Researchers urge more studies of link between PCBs and brain cancer
  • increased incidence of brain cancer among workers who had more than twice the estimated cumulative PCB dose than the comparison group
  • PCB-exposed workers experienced excess in the number of deaths resulting from brain cancer
  • elevated risks of brain cancer have been noted in electrical workers, who tend to be exposed to PCBs
  • Brain cancer was significantly increased in females exposed to dioxin [certain PCBs are dioxin-like, or contaminated with dioxin]
  • A statistically significant higher concentration of PCB was found in extracted lipids of adipose tissue samples from terminal brain cancer patients
  • Nerve Growth Factor (NGF) was more potent in the presence of PCBs
  • PCBs have the potential to influence the NGF neurotrophic system
  • children of fathers exposed to dioxin experienced increased rates of brain cancer
  • there is suggestive evidence that brain tumors are associated with parental exposures to chemicals
  • causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection
  • A glioma case [brain cancer] was associated with dioxin exposure
  • alteration of cellular redox balance may mediate the dioxin-induced inhibition of proliferation in human neuronal cells.

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