References --- PCBs and Kidney, Bladder or Urothelial Cancers

Arai M, Hibino T, Takino H, Ouchi N, Hirasawa Y.   Comparative Enhancing Effects Of Polychlorinated Biphenyls And Phenobarbital On Dimethylnitrosamine-Induced Hepatic And Renal Tumorigenesis In Rats.  Source: Developments in Toxicology and Environmental Science, Vol. 11 - Developments in the Science and Practice of Toxicology, pages 359-362, 5 ref, 1983.

Azais V, Pascal G, Arand M, Oesch F, Robertson LW.   Effects of Congeneric Polychlorinated Biphenyls on Liver and Kidney Retinoid Levels.  Chemosphere, Vol. 15, Nos. 9-12, pages 1905-1908, 11 references, 1986

Azais V, Arand M, Rauch P, Schramm H, Bellenand P, Narbonne J-F, Oesch F, Pascal G, Robertson LW.   A Time-Course Investigation of Vitamin A Levels and Drug Metabolizing Enzyme Activities in Rats Following a Single Treatment with Prototypic Polychlorinated Biphenyls and DDT.  Toxicology, Vol. 44, No. 3, pages 341-354, 53 references, 1987 

BEEBE LE, FORNWALD LW, ALWORTH WL, DRAGNEV KH, LUBET RA.  Effect of dietary Aroclor 1254 exposure on lung and kidney cytochromes P450 in female rats: Evidence for P4501A2 expression in kidney.  CHEMICO-BIOLOGICAL INTERACTIONS; 97 (3). 1995. 215-227.  Author Address: Lab. Comp. Carcinog., Natl. Cancer Inst.-Frederick Cancer Res. Dev. Cent., Frederick, MD 21702, USA. 

BELLETTI I, TROSCHEL L, PISANI P, BERRINO F.   Retrospective assessment of exposure by experts: The example of formaldehyde, solvents and mineral oils among textile and metal workers.  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY; 22 (6 SUPPL. 2). 1993. S127-S133. Author Address: Epidemiol. Div., Ist. Nazionale Tumori, Via Venezian 1, I-20133 Milan, ITL. 

Brandt I, Bergman A.   PCB Methyl Sulphones and Related Compounds: Identification of Target Cells and Tissues in Different Species.  Chemosphere, Vol. 16, Nos. 8/9, pages 1671-1676, 23 references, 1987

CAPPON ID, YOUNG ET, NICHOLLS DM.   An environmental chemical, polychlorinated biphenyl, increases the protein synthesizing activity of liver and kidney pH 5 supernatant fractions.  CHEM-BIOL INTERACT; 14 (1-2). 1976 127-134.  Author Address: Dep. Biol., York Univ., 4700 Keele St., Downsview, Ont. M3J 1P3, Can.

Chu I, Villeneuve DC, Yagminas A, Lecavalier P, Hakansson H, Ahlborg UG, Valli VE, Kennedy SW, Bergman A, Seegal RF, Feeley M.   Toxicity of PCB 77 (3,3'4,4'-Tetrachlorobiphenyl) and PCB 118 (2,3'4,4'5-Pentachlorobiphenyl) in the Rat following Subchronic Dietary Exposure. Source: Fundamental and Applied Toxicology, Vol. 26, No. 2, pages 282-292, 28 references, 1995

Cordier S., Fréry N., Le Goaster C., Marquis M., “Accident au Pyralène : suivi médical 10 ans après,”  Bulletin Epidémiologique Hebdomadaire, n°40/1996, p175, Ministry of Labour and Social Affairs, General Directorate of Health, France.  Found on: http://www.greenpeace.org/~toxics/html/content/franceinfo1.html

Greenland S, Salvan A, Wegman DH, Hallock MF, Smith TJ.   A Case-Control Study of Cancer Mortality at a Transformer-Assembly Facility. International Archives of Occupational and Environmental Health, Vol. 66, No. 1, pages 49-54, 16 references, 1994

HIROSE M, SHIRAI T, TSUDA H, FUKUSHIMA S, OGISO T, ITO N.   EFFECT OF PHENOBARBITAL, POLYCHLORINATED BIPHENYL AND SODIUM SACCHARIN ON HEPATIC AND RENAL CARCINOGENESIS IN UNILATERALLY NEPHRECTOMIZED RATS GIVEN N-ETHYL-N-HYDROXYETHYLNITROSAMINE ORALLY.  Source: CARCINOGENESIS 1981, 2(12) 1299-1302

Kluwe WM, McCormack KM, Hook JB.   Selective modification of the renal and hepatic toxicities of chloroform by induction of drug-metabolizing enzyme systems in kidney and liver.  J. Pharmacol. Exp. Ther. 207(2): 566-573 1978 (50 References). Author Address: Dep. Pharmacol. Toxicol., Michigan State Univ., East Lansing, MI 48824 

KLUWE WM, HERRMANN CL, HOOK JB.   Effects of dietary polychlorinated biphenyls and polybrominated biphenyls on the renal and hepatic toxicities of several chlorinated hydrocarbon solvents in mice.   J TOXICOL ENVIRON HEALTH; 5 (4). 1979. 605-616.  Author Address: Dep. Pharmacol., Mich. State Univ., East Lansing, Mich. 48824, USA. 

Koponen K, Myers MS, Ritola O, Huuskonen SE, Lindstrom-Seppa P.  Histopathology of feral fish from a PCB-contaminated freshwater lake.  Ambio 2001 May;30(3):122-6.  University of Kuopio, Department of Physiology, P.O.B. 1627, FIN-70211 Kuopio, Finland. kari.koponen@pp6.inet.fi

Longnecker, M.P., W.J. Rogan and G. Lucier, “The Human Health Effects of DDT   (dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and an Overview of Organochlorines In Public Health,” Annual Review of Public Health, 18:211-244, 1997.  Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. longnecker@niehs.nih.gov

LOPEZ-APARICIO P, MERINO MJ, SANCHEZ E, RECIO MN, PEREZ-ALBARSANZ MA.  Effect of aroclor 1248 and two pure PCB congeners upon the membrane fluidity of rat renal tubular cell cultures.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY; 57 (1). 1997. 54-62. Author Address: Dep. Bioquim. Biol. Mol., Univ. Alcala, 28871 Alcala de Henares, Madrid, Spain. 

Nath RG, Randerath E, Randerath K.  Short-term effects of the tumor promoting polychlorinated biphenyl mixture, Aroclor 1254, on I-compounds in liver, kidney and lung DNA of male Sprague-Dawley rats.  Toxicology 1991;68(3):275-89. Author Address: Division of Toxicology, Department of Pharmacology, Baylor College of Medicine, Houston, TX.

Peakall DB, Lincer JL.   Polychlorinated biphenyls, another long-life widespread chemical in the environment.  BioScience; 20(17): 958-64 1970; (REF:62) 

Perez-Reyes PL, Sanchez-Alonso JA, Lopez-Aparicio P, Recio MN, Perez-Albarsanz MA.  Different molecular capacity in the induction of apoptosis by polychlorinated biphenyl congeners in rat renal tubular cell cultures.  Biosci Rep 2001 Dec;21(6):765-78. Departamento de Bioquimica y Biologia Molecular, Universidad de Alcala, Alcala de Henares-Madrid, Spain.

PLATO N, STEINECK G.   METHODOLOGY AND UTILITY OF A JOB-EXPOSURE MATRIX.   Source: AM J IND MED; 23 (3). 1993. 491-502. 

Ramlow JM, Spadacene NW, Hoag SR, Stafford BA, Cartmill JB, Lerner PJ.   Mortality in a Cohort of Pentachlorophenol Manufacturing Workers, 1940-1989.  Source: American Journal of Industrial Medicine, Vol. 30, No. 2, pages 180-194, 54 references, 1996

Shalat SL, True LD, Fleming LE, Pace PE.  Kidney Cancer in Utility Workers Exposed to Polychlorinated Biphenyls (PCBs). British Journal of Industrial Medicine, Vol. 46, No. 11, pages 823-824, 19 references,1989 

SODERLUND EJ, NELSON SD, DYBING E.  In vitro and in vivo covalent binding of the kidney toxicant and carcinogen tris(2,3-dibromopropyl)-phosphate.    TOXICOLOGY; 21 (4). 1981. 291-304.  Author Address: Dep. Toxicol., National Inst. Public Health, Postuttak, Oslo 1, Norway. 

Soffientino B, Nacci D, Specker JL.   Toxicity of CB 126 in metamorphosing summer flounder larvae.  Toxicologist 2002 Mar;66(1-S):112  Author Address: Graduate School of Oceanography, University of Rhode Island,  Narragansett, RI.

Steele G, Smith AB, Bernert JT, Hannon WH.  Health Hazard Evaluation Report No. HETA-84-339-2052, Westinghouse Electric Company, Bloomington, Indiana.  Source: Hazard Evaluation and Technical Assistance Branch, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. HETA-84-339-2052, 104 pages, 29 references, 1990 

Steineck G, Plato N, Alfredsson L, Norell SE.   Industry-Related Urothelial Carcinogens: Application of a Job-Exposure Matrix to Census Data. American Journal of Industrial Medicine, Vol. 16, No. 2, pages 209-224, 43 references, 1989

Steineck G, Plato N, Gerhardsson M, Norell SE, Hogstedt C.   Increased Risk of Urothelial Cancer in Stockholm during 1985-87 after Exposure to Benzene and Exhausts.  Source: International Journal of Cancer, Vol. 45, No. 6, pages 1012-1017, 29 references, 1990a 

STEINECK G, PLATO N, NORELL SE, HOGSTEDT C.   Urothelial cancer and some industry-related chemicals: An evaluation of the epidemiologic literature.   AM J IND MED; 17 (3). 1990b. 371-392. Author Address: Radiumhemmet, Karolinska Hosp., S-104 01 Stockholm 60, Sweden. 

Steineck G.  Epidemiological studies on urothelial cancer. Arbetsmiljèoinstitutet, Fèorlagstjèanst, 171 84 Solna, Sweden, 1990c. 76p. 146 ref. 

Go to:

Introduction to PCBs and Kidney Cancer

Summary of Study Results

Studies of PCBs and Kidney, Bladder and Urothelial Cancers

Links to More Information