Parkinson’s Disease, Dopamine and PCBs

Links to More Information
on Parkinson's Disease and Dopamine

Parkinson's Disease, Dopamine and PCBs
The National Parkinson Foundation, Inc.
SmithCline Beecham
D opamine - A Sample Neurotransmitter, College of Pharmacy, Univ. of Texas
The Dopamine Hypothesis of Schizophrenia
The Dopamine D2 Receptor as a Candidate Gene for Alcoholism
Other Neurotransmitters, The College of Pharmacy, Univ. of Texas
Neurons
Neurotransmission
Brain Briefings --- Parkinson’s Disease
Team Dopamine --- Research
Dopamine, Pharmacologic and Therapeutic Aspects

References - linking Parkinson's Disease, Dopamine and PCB Exposure

Angus WG, Contreras ML. The effects of Aroclor 1254 on undifferentiated and NGF-stimulated differentiating PC12 cells. Neurotoxicology; VOL 15, ISS 4, 1994, P809-18. Author Address: Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA.

Angus WGR, Contreras ML. Effects of Polychlorinated Biphenyls on Dopamine Release from PC12 Cells. Toxicology Letters, Vol. 89, No. 3, pages 191-199, 34 references, 1996

Angus WG, Mousa MA, Vargas VM, Quensen JF, Boyd SA, Contreras ML. Inhibition of L-aromatic amino acid decarboxylase by polychlorinated biphenyls. Neurotoxicology; VOL 18, ISS 3, 1997, P857-67. Author Address: Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA.

Bemis JC, Seegal RF. Polychlorinated biphenyls and methylmercury act synergistically to reduce rat brain dopamine content in vitro. Environ Health Perspect; VOL 107, ISS 11, 1999, P879-85. Author Address: School of Public Health, University at Albany, Albany, New York, USA.

Chauhan KR, Kodavanti PR, McKinney JD. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol Appl Pharmacol; VOL 162, ISS 1, 2000, P10-21. Author Address: Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina,USA. chauhan.kamal@epamail.epa.gov

CHISHTI MA, FISHER JP, SEEGAL RF. Aroclors 1254 and 1260 reduce dopamine concentrations in rat striatal slices.

NEUROTOXICOLOGY (LITTLE ROCK); 17 (3-4). 1996. 653-660. Author Address: Sch. Public Health, Univ. Albany, Empire State Plaza, Box 509, Albany, NY 12201-0509, USA.

Choksi NY, Kodavanti PRS, Tilson HA, Booth RG. Effects of Polychlorinated Biphenyls (PCBs) on Brain Tyrosine Hydroxylase Activity and Dopamine Synthesis in Rats. Fundamental and Applied Toxicology, Vol. 39, No. 1, pages 76-80, 28 references, 1997

Chu I, Villeneuve DC, Yagminas A, Lecavalier P, Hakansson H, Ahlborg UG, Valli VE, Kennedy SW, Bergman A, Seegal RF, Feeley M. Toxicity of PCB 77 (3,3'4,4'-Tetrachlorobiphenyl) and PCB 118 (2,3'4,4'5-Pentachlorobiphenyl) in the Rat following Subchronic Dietary Exposure. Fundamental and Applied Toxicology, Vol. 26, No. 2, pages 282-292, 28 references, 1995

Chu I, Villeneuve DC, Yagminas A, Lecavalier P, Poon R, Hêakansson H, Ahlborg UG, Valli VE, Kennedy SW, Bergman A, Seegal RF, Feeley M. Toxicity of 2,4,4'-trichlorobiphenyl in rats following 90-day dietary exposure. J Toxicol Environ Health; VOL 49, ISS 3, 1996, P301-18. Author Address: Environmental Health Directorate, Health Protection Branch, Ontario, Canada.

Corrigan FM, Murray L, Wyatt CL, Shore RF. Diorthosubstituted polychlorinated biphenyls in caudate nucleus in Parkinson's disease. Exp Neurol; VOL 150, ISS 2, 1998, P339-42. Author Address: Argyll and Bute NHS Trust, Argyll and Bute Hospital, Lochgilphead, PA31 8LD, United Kingdom.

Fredriksson A, Fredriksson M, Eriksson P. Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice. Toxicol Appl Pharmacol; VOL 122, ISS 2, 1993, P258-64. Author Address: Department of Toxicology, Uppsala University, Sweden.

Guarisco JA, Carr RI, Chambers JE. The effects of developmental exposure to polychlorinated biphenyls on D1 and D2 dopamine receptors in juvenile and adult rats. Toxicologist 1999 Mar;48(1-S):288. Author Address: Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS.

German Govt. Report (Anonymous). Untersuchungen zum Einfluss von Schadstoffen auf funktionelle Parameter der zellulaeren Reaktivitaet und der Freisetzung von Mediatoren der Entzuendung. Abschlussbericht. (Investigations on the influence of toxic substances on functional parameters of cellular reactivity and of the release of mediat. Govt Reports Announcements & Index (GRA&I), Issue 07, 1993. Author Address: Ruhr Univ., Bochum (Germany, F.R.). Lehrstuhl fuer Medizinische Mikrobiologie und Immunologie.

Giesy JP, Kannan K. Dioxin-like and non-dioxin-like toxic effects of polychlorinated biphenyls (PCBs): implications for risk assessment. Crit Rev Toxicol; VOL 28, ISS 6, 1998, P511-69 (REF: 286). Author Address: Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA.

Kodavanti PR, Shin DS, Tilson HA, Harry GJ. Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Toxicol Appl Pharmacol; VOL 123, ISS 1, 1993, P97-106. Author Address: Cellular and Molecular Toxicology Branch, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.

Lilienthal H, Weinand-Harer A, Winneke G. Drug discrimination in rats following maternal exposure to a coplanar PCB or propylthiouracil. Toxicologist 1996 Mar;30(1 Pt 2):227. Author Address: Medical Institute of Environmental Hygiene, Dusseldorf, Germany.

Lilienthal H, Weinand-Harer A, Winterhoff H, Winneke G. Effects of maternal exposure to 3,3',4,4'-tetrachlorobiphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicol Appl Pharmacol 1997 Sep;146(1):162-9 Author Address: Department of Biological Psychology, Heinrich-Heine-University, Auf'm Hennekamp 50, Duesseldorf, D-40225, Germany.

Mariussen E, Morch Andersen J, Fonnum F. The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles. Toxicol Appl Pharmacol; VOL 161, ISS 3, 1999, P274-82. Author Address: Norwegian Defence Research Establishment, Kjeller, 2027, Norway. espen.mariussen@ffi.no

Morse DC, Seegal RF, Borsch KO, Brouwer A. Long-Term Alterations in Regional Brain Serotonin Metabolism Following Maternal Polychlorinated Biphenyl Exposure in the Rat. Neurotoxicology, Vol. 17, Nos. 3/4, pages 631-638, 38 references, 1996

Nagaoka S, Kato M, Aoyama Y, Yoshida A. Comparative studies on the hypercholesterolaemia induced by excess dietary tyrosine or polychlorinated biphenyls in rats. Br J Nutr; VOL 56, ISS 2, 1986, P509-17. Author Address: Department of Agricultural Chemistry, Nagoya University, Japan.

Sauer PJ, Huisman M, Koopman-Esseboom C, Morse DC, Smits-van Prooije AE, van de Berg KJ, Tuinstra LG, van der Paauw CG, Boersma ER, Weisglas-Kuperus N, et al. Effects of polychlorinated biphenyls (PCBs) and dioxins on growth and development. Hum Exp Toxicol 1994 Dec;13(12):900-6. Author Address: Department of Paediatrics, Erasmus University, Rotterdam, The Netherlands.

Seegal RF, Brosch KO, Bush B. Polychlorinated biphenyls produce regional alterations of dopamine metabolism in rat brain. Toxicol Lett; VOL 30, ISS 2, 1986, P197-202

Seegal RF, Bush B, Shain W. Lightly Chlorinated ortho-Substituted PCB Congeners Decrease Dopamine in Nonhuman Primate Brain and in Tissue Culture. Source: Toxicology and Applied Pharmacology, Vol. 106, No. 1, pages 136-144, 70 references, 1990

Seegal RF, Bush B, Brosch KO. Sub-chronic Exposure of the Adult Rat to Aroclor 1254 Yields Regionally-Specific Changes in Central Dopaminergic Function. Neurotoxicology, Vol. 12, No. 1, pages 55-65, 54 references, 1991

Seegal RF, Bush B, Brosch KO. Comparison of Effects of Aroclors 1016 and 1260 on Non-human Primate Catecholamine Function. Source: Toxicology, Vol. 66, No. 2, pages 145-163, 65 references, 1991

Seegal RF. Perinatal exposure to Aroclor 1016 elevates brain dopamine concentrations in the rat. Toxicologist 1992 Feb;12(1):320 Author Address: Wadsworth Center, NYS Dept. of Health, School of Public Health, Albany, NY.

Seegal RF, Bush B, Brosch KO. Decreases in Dopamine Concentrations in Adult, Non-human Primate Brain Persist following Removal from Polychlorinated Biphenyls. Toxicology, Vol. 86, Nos. 1/2, pages 71-87, 29 references, 1994

Seegal RF, Schantz SL. Neurochemical and Behavioral Sequelae of Exposure to Dioxins and PCBs. Dioxins and Health, A. Schecter, Editor; Plenum Press, New York, pages 409-447, 153 references, 1994

Seegal RF, Brosch KO, Okoniewski RJ. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 1997 Sep;146(1):95-103. Author Address: New York State Department of Health, University at Albany, Albany, New York 12201-0509, USA.

Seegal RF. Neurochemical effects of co-planar and non-coplanar polychlorinated biphenyls. Neurotoxicol Teratol 1998 May/Jun;20(3):349-50. Author Address: Wadsworth Center, New York State Department of Health, Albany, NY.

Seegal RF. Are PCBs the major neurotoxicant in Great Lakes salmon? Environ Res 1999 Feb;80(2 Pt 2):S38-S45

Author Address: New York State Department of Health, Albany, New York, 12201-0509, USA.

Seegal RF, Bemis JC. Polychlorinated biphenyls and methylmercury synergistically alter dopamine and intracellular calcium. Neurotoxicology 2000 Feb-Apr;21(1-2):243. Author Address: Wadsworth Center, New York State Department of Health, Albany, NY.

Shain W, Bush B, Seegal R. Neurotoxicity of Polychlorinated Biphenyls: Structure-Activity Relationship of Individual Congeners Toxicology and Applied Pharmacology, Vol. 111, No. 1, pages 33-42, 40 references, 1991 Author Address: Laboratory of Neurotoxicology and Nervous System Disorders, Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.

Smith CR, Barker CM, Barker LF, Jessen-Eller K, Reinisch CL. Polychlorinated biphenyls (PCBs) selectively disrupt serotonergic cell growth in the developing Spisula embryo. Toxicol Sci; VOL 50, ISS 1, 1999, P54-63. Author Address: Department of Environmental and Population Health, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA.

SWEET LI, PASSINO-READER DR, MEIER PG, OMANN GM. Xenobiotic-induced apoptosis: Significance and potential application as a general biomarker of response. BIOMARKERS; 4 (4). 1999. 237-253. Author Address: Department of Environmental and Industrial Health, School of Public Health, The University of Michigan, Ann Arbor, MI, 48109, USA.

Tilson HA, Kodavanti PRS. Neurochemical Effects of Polychlorinated Biphenyls: An Overview and Identification of Research Needs. Neurotoxicology, Vol. 18, No. 3, pages 727-744, 86 references, 1997

TILSON HA, KODAVANTI P RS. The neurotoxicity of polychlorinated biphenyls. NEUROTOXICOLOGY (LITTLE ROCK); 19 (4-5). 1998. 517-526. Author Address: Neurotoxicology, Div., Natl. Health Environ. Effects Res. Lab., US Environ. Protection Agency, Research Triangle Park, NC 27711, USA.

Zahalka EA, Stanton ME, Rehnberg GL, Goldey ES, Ellis DH, Lau C. Perinatal exposure to Aroclor 1016 reduced plasma thyroxine but did not alter brain catecholamines or maze learning in the rat. Teratology 1994 May;49(5):395. Author Address: Toxicology Program, University of North Carolina, Chapel Hill, NC.