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References --- Dioxins and Prostate Cancer
Bjerke DL, Sommer RJ, Moore RW, Peterson RE. Perinatal exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can decrease responsiveness to androgens in adulthood. Toxicologist 1993 Mar;13(1):104. Author Address: School of Pharmacy, Univ. of Wisconsin, Madison, WI. Bjerke DL, Sommer RJ, Moore RW, Peterson RE. Effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on responsiveness of the male rat reproductive system to testosterone stimulation in adulthood. Toxicol Appl Pharmacol 1994 Aug;127(2):250-7.Author Address: School of Pharmacy, University of Wisconsin, Madison 53706. Bjerke DL, Peterson RE. Reproductive toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male rats: different effects of in utero versus lactational exposure. Toxicol Appl Pharmacol 1994 Aug;127(2):241-9. Author Address: School of Pharmacy, University of Wisconsin, Madison 53706. Gray LE Jr, Kelce WR, Monosson E, Ostby JS, Birnbaum LS. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol Appl Pharmacol 1995 Mar;131(1):108-18. Author Address: Developmental Reproductive Biology Section, DTD, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. Gray LE, Ostby JS, Kelce WR. A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans Hooded rat offspring. Toxicol Appl Pharmacol 1997 Sep;146(1):11-20. Author Address: Reproductive Toxicology Division, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. Ko K, Moore RW, Peterson RE. Lobe-specific effects of in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on branching morphogenesis in mouse prostate. Toxicologist 2001 Mar;60(1):273 Author Address: University of Wisconsin, School of Pharmacy, Madison, WI. LEE IP, SUZUKI K. Induction of aryl hydrocarbon hydroxylase (EC 1.14.14.1) activity in the rat prostate glands by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J PHARMACOL EXP THER; 215 (3). 1980 (RECD. 1981). 601-605. Author Address: Lab. Reprod. Dev. Toxicol., Natl. Inst. Health, P.O. Box 12233, Research Triangle Park, N.C. 27709. LEE IP, SUZUKI K, NAGAYAMA J. Metabolism of benzo(a)pyrene in rat prostate glands following 2,3,7,8-tetrachlorodi-benzo-p-dioxin exposure. CARCINOGENESIS (LOND); 2 (9). 1981. 823-832. Author Address: Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Lin TM, Ko K, Ohtani S, Peterson RE. Ah receptor (AhR) in mouse prostate growth and development: physiological role and role in mediating TCDD effects. Toxicologist 2000 Mar;54(1):136. Author Address: University of Wisconsin, Madison, WI. Lin TM, Rasmussen NT, Peterson RE. Prenatal 5alpha-dihydrotestosterone (DHT) treatment does not protect against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced inhibition of prostatic bud formation. Toxicologist 2001 Mar;60(1):270. Author Address: University of Wisconsin, School of Pharmacy, Madison, WI. Loeffler IK, Peterson RE. Interactive effects of TCDD and p,p'-DDE on male reproductive tract development in in utero and lactationally exposed rats. Toxicol Appl Pharmacol 1999 Jan 1;154(1):28-39. Author Address: School of Pharmacy and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, 53706, USA. Mably TA, Moore RW, Peterson RE. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Effects on androgenic status. Toxicol Appl Pharmacol 1992 May;114(1):97-107. Author Address: School of Pharmacy, University of Wisconsin, Madison 53706. Moore RW, Mably TA, Peterson RE. Effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) exposure on the development of male rats and their androgenic status.
Toxicologist 1990 Feb;10(1):247
Moore RW, Mably TA, Bjerke DL, Peterson RE. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decreases androgenic responsiveness of male sex organs and permanently inhibits spermatogenesis and demasculinizes sexual behavior in rats. Toxicologist 1992 Feb;12(1):81. Author Address: Sch. of Pharmacy and Environ. Toxicol. Ctr., Univ. Wisc., Medison, WI. Ohsako S, Nishimura N, Miyabara Y, Ishizuka M, Aoki Y, Tohyama C, Sone H, Yonemoto J. Changes in the reproductive organs of the male rats exposed maternally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicologist 1999 Mar;48(1-S):148. Author Address: Environmental Health Sciences Division, NIES, Tsukuba, Ibaraki, Japan. Richardson VM, Hamm JT, Birnbaum LS. Time-dependent effects on gene expression in rat seminal vesicle developmentally altered by in utero exposure to TCDD. Toxicologist 2001 Mar;60(1):273. Author Address: USEPA, ORD/NHEERL/ETD, Research Triangle Park, NC. Roman BL, Sommer RJ, Shinomiya K, Peterson RE. Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) decreases androgen-dependent organ weights in male rats without inhibiting testicular androgen production. Toxicologist 1994 Mar;14(1):382. Author Address: Environmental Toxicology Center, University of Wisconsin, Madison, WI. Roman BL, Sommer RJ, Shinomiya K, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin: impaired prostate growth and development without inhibited androgen production. Toxicol Appl Pharmacol 1995 Oct;134(2):241-50. Author Address: Environmental Toxicology Center, University of Wisconsin, Madison 53706, USA. Roman BL, Peterson RE, Timms BG, Barton LD, Burbach A, vom Saal F. In utero 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure decreases the number of epithelial buds in the fetal rat prostate. Toxicologist 1996 Mar;30(1 Pt 2):144-5. Author Address: Environmental Toxicology Center, Madison, WI. Roman BL, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development. 1. Effects on gene expression. Toxicol Appl Pharmacol 1998a Jun;150(2):240-53. Author Address: Environmental Toxicology Center, University of Wisconsin, Madison 53706, USA. Roman BL, Timms BG, Prins GS, Peterson RE. In utero and lactational exposure of the male rat to 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs prostate development. 2. Effects on growth and cytodifferentiation. Toxicol Appl Pharmacol 1998b Jun;150(2):254-70. Author Address: Environmental Toxicology Center, University of Wisconsin, Madison 53706, USA. Simanainen U, Lin TM, Peterson RE. Assessment of the ages at which ventral prostate development in mice is most vulnerable to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. Toxicologist 2001 Mar;60(1):333. Author Address: University of Wisconsin-Madison, School of Pharmacy, Madison, WI. Sommer RJ, Sojka KM, Pollenz RS, Cooke PS, Peterson RE. Ah receptor and ARNT protein and mRNA concentrations in rat prostate: effects of stage of development and 2,3,7, 8-tetrachlorodibenzo-p-dioxin treatment. Toxicol Appl Pharmacol 1999 Mar 1;155(2):177-89. Author Address: School of Pharmacy, University of Wisconsin, Madison, Wisconsin, 53706, USA. Theobald HM, Peterson RE. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-rho-dioxin: effects on development of the male and female reproductive system of the mouse. Toxicol Appl Pharmacol 1997 Jul;145(1):124-35. Author Address: School of Pharmacy, University of Wisconsin, Madison 53706, USA. Theobald HM, Roman BL, Lin TM, Ohtani S, Chen SW, Peterson RE. 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits luminal cell differentiation and androgen responsiveness of the ventral prostate without inhibiting prostatic 5alpha-dihydrotestosterone formation or testicular androgen production in rat offspring. Toxicol Sci 2000 Dec;58(2):324-38. Author Address: School of Pharmacy and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53706, USA. Wilker C, Johnson L, Safe S. Effects of developmental exposure to indole-3-carbinol or 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive potential of male rat offspring. Toxicol Appl Pharmacol 1996 Nov;141(1):68-75. Author Address: Department of Veterinary Anatomy and Public Health, Texas A&M University, College Station 77843-4466, USA. Yonemoto J, Sone H, Ohsako S, Nishimura N, Nohara K, Fujimaki H, Ushio H, Miyabara Y, Aoki Y, Ishizuka M, et al. Effects of maternal exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Sci 1999 Oct;24(4):298. Author Address: Regional Environ. Div., Natl. Inst. for Environ. Studies, Tsukuba, Japan. Yonemoto J, Ichiki T, Tohyama C. Reproductive effects of offspring exposed maternally to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and association of the effects with the body burdens in dams and fetuses/pups in Long-Evans rats. Toxicologist 2001 Mar;60(1):274. Author Address: National Institute for Environmental Studies, Tsukuba, Japan. Yonemoto J. Developmental effects of a single gestational dose of TCDD in Holtzman rat offspring. Teratology 2001 Apr;63(4):9A. Author Address: National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan.
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